Cross-linked Povidone Uses

Cross-linked povidone is a water-insoluble tablet disintegrant that quickly exhibits high capillary activity and excellent hydration ability, with almost no tendency to gel; studies have shown that the size of cross-linked povidone particles strongly affects Regarding the disintegration of antipyretic and analgesic tablets, crospovidone with larger particles can disintegrate faster than smaller particles. Crospovidone is a very good disintegrant. The dosage in tablets is generally 1-2%, which can achieve the disintegration effect of other commonly used ordinary disintegrants. It is called a super disintegrant.
Cross-linked povidone can also be used as a dry binder, filler and excipient for tablets, capsules and granules. The smaller particle size can reduce the markings on the tablet surface and improve the texture of the tablet. Uniformity, the usual dosage is 20-80mg/tablet.
Crospovidone can also be used as a dissolution accelerator. Co-evaporation technology can be used to increase the solubility of poorly soluble drugs: first, an appropriate solvent is used to adsorb the drug to crospovidone, and then the solvent is evaporated. This technology can Get faster dissolution rates.
This product is also widely used as a filter aid in wine making and vinegar production in the food industry to remove enzymes and proteins.
Cross-linked povidone and polyphenols can form stable complexes, which can be used to refine water-soluble or alcohol-containing herbal extracts and tinctures to improve the stability of plant medicines.