Polyvinylpyrrolidone Applications

As a synthetic water-soluble polymer compound, PVP has the general properties of water-soluble polymer compounds, including colloidal protective effects, film-forming properties, adhesion, hygroscopicity, solubilization or aggregation, but it is the most distinctive and therefore is subject to People attach great importance to its excellent solubility and physiological compatibility. Among synthetic polymers, PVP is soluble in both water and most organic solvents, has very low toxicity, and has good physiological compatibility. It is rare, especially in medicine, food, and cosmetics, which are closely related to people's health. In the field, as the price of its raw material butyrolactone decreases, it will definitely show good prospects for its development. The following is a detailed introduction to its application fields:
Medicine & Health
PVP has excellent physiological inertness, does not participate in human metabolism, and has excellent biocompatibility. It does not cause any irritation to skin, mucous membranes, eyes, etc. Pharmaceutical grade PVP is one of the three new pharmaceutical excipients advocated internationally. It can be used as a binder for tablets and granules, a cosolvent for injections, and a flow aid for capsules; as a detoxifier, prolongation agent, and lubricant for eye drops. Agents and coating film-forming agents, dispersants for liquid preparations and stabilizers for enzymes and heat-sensitive drugs, and can also be used as cryogenic preservatives. Used in contact lenses to increase their hydrophilicity and lubricity. PVP K30 has been approved by the national pharmaceutical regulatory authorities and officially launched on the market. The company also supplies povidone K30 with an approval number. [1]
From a biological point of view, the molecular structure of PVP is similar to that of a simple protein model, even its water solubility, ability to cooperate with certain small molecules, and its ability to be precipitated by certain protein precipitants such as ammonium sulfate and ammonium sulfate. Precipitating properties such as trichloroacetic acid, tannins and phenols are also compatible with proteins. As a result, PVP is widely used as an excipient for pharmaceutical preparations. The specific applications are as follows: ① Used as a binder for preparations ② Co-precipitating agent ③ As a co-solvent or crystallization inhibitor in injections ④ Coating or film-forming agent ⑤ The controlled release of delaying agents and sustained-release drugs can extend the action time of the drugs ⑥ Artificial vitreous body and cornea ⑦ Surgical dressing tape ⑧ PVP iodine disinfectant. In addition, PVP can also be used as a colorant and X-ray contrast agent; it can be used in various dosage forms such as tablets, granules, and liquids. It has the functions of detoxification, hemostasis, increasing dissolution concentration, preventing peritoneal adhesion, and promoting erythrocyte sedimentation rate.
food processing
PVP itself is not carcinogenic, has good food safety, and can form complexes with specific polyphenol compounds (such as tannins). In food processing, it is mainly used as a clarifier and stabilizer for beer, juice, wine and other food products. PVP can form complexes with specific polyphenolic compounds (such as tannins), allowing it to play a clarifying and anti-coagulant role in fruit drinks. For example, Buschke H and others added 0.01% ~0.02% soluble PVP to the fermentation tank, which can effectively reduce its freezing point. The use of PVP in the production process of wine, vinegar, etc. can also have the same effect. Cross-linked PVP is particularly widely used in beer and tea beverages. Polyphenols in beer can combine with proteins in beer to form tannin macromolecular complexes, which will seriously affect the flavor of beer and shorten its shelf life. Cross-linked polyvinylpyrrolidone (PVPP) can complex with tannins and anthocyanins in beer, thereby clarifying the beer, improving the storage stability of the beer, and extending the shelf life. In tea beverages, the use of PVPP can appropriately reduce the content of tea polyphenols, and PVPP does not remain in tea beverages and can be reused, greatly reducing costs. 
Daily cosmetics
In the consumption structure of PVP, the cosmetics industry in developed countries accounts for 30% to 50%, and my country accounts for 70% to 80%. Since PVP has extremely low toxicity and physiological inertness, it is non-irritating to the skin and eyes, and has a long-term record of use in the medical field, so it is safe to be used in cosmetics, etc. In daily cosmetics, PVP and copolymers have good dispersion and film-forming properties. PVP has a protective colloid effect in emulsions and can be used in fatty and non-fatty pastes as setting liquid, hair spray and friction. Styling agent for silk, opacifier for hair conditioner, foam stabilizer for shampoo, dispersing agent and affinity agent for wave styling agent and hair dye. Adding PVP to creams, sunscreens, and hair removers can enhance the moisturizing and lubricating effects.