Va 64 Powder25086-89-9

Va 64 Powder25086-89-9

Povidone VA64 is a polymer material with multiple functions and is commonly used in industries such as medicine and cosmetics. Its main function is to absorb water and thicken, so it is widely used in pharmaceutical formulations in the form of tubes or capsules.
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Product Introduction
Product Introduction

 

Povidone VA64 is a polymer material with multiple functions and is commonly used in industries such as medicine and cosmetics. Its main function is to absorb water and thicken, so it is widely used in pharmaceutical formulations in the form of tubes or capsules. It can also be used in the preparation of drugs such as eye drops and seawater nasal sprays, as it stabilizes drug formulations and has good drug delivery capabilities.


VA 64 Powder 25086-89-9 (CAS 25086-89-9) is a vinylpyrrolidone-vinyl acetate copolymer (60:40 ratio) meeting USP/Ph.Eur standards. K-value 28-32. White free-flowing powder for solid dosage formulations.
 

In addition, Povidone VA64 can also be used as an excellent lubricant and anti-sticking agent, and is widely used in gynecological examinations and surgeries to prevent glove adhesion. In addition, it is also used in oral sanitizers, deodorants, sterilizers, and toothpastes with excellent antibacterial properties and bactericidal properties.

 

In general, Povidone VA64 is a multi-functional polymer material, which has the properties of water absorption, thickening, lubrication, anti-sticking, sterilization, disinfection, etc., and is widely used in medicine and cosmetics.
 

Core Functions

 

◣Instant dissolution: <5 min disintegration in IR tablets

◣Melt extrusion:Matrix former for HME processing (Tg 106°C)

◣Bioavailability enhancement:Solid dispersions for BCS II/IV drugs

◣Moisture protection:Hygroscopic API barrier in humid climates

◣Direct compression:Dry binder reducing friability ≤0.5%
 

 
 
Release Testing Data

Parameter

Specification

CAS No

25086-89-9

VP:VA Ratio

60:40 ±2% (NMR)

Residual NVP

≤100 ppm (GC)

Loss on Drying

≤5.0% (105°C)

Bulk Density

0.40–0.55 g/cm³

Compliance

USP-NF <1057>, Ph.Eur 10.0

 

Processing Notes

 

 

1.HME Parameters:130–180°C melt temp (DSC data available)

2.Compression:Maintain RH <60% during tableting

3.Reactivity:Avoid strong oxidizers (decarbonylation >200°C)

4.Packaging:25kg PE-lined drums, nitrogen flushed

Supply Advantages

 

◎Regulatory:EDQM CEP on request

◎Consistency:Batch-specific K-value reports (28-32)

◎Scale:50kg to 10 MT production runs

◎Stability:36-month shelf life (<25°C/60% RH)

 

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