Crospovidone Vs Copovidone25249-54-1

pients and active ingredients have very good compatibility. Solid drugs containing PVPP tablet disintegrants can use common tablet production techniques, including direct compression, It is easy to produce by spraying, drying and wet granulation. Compressibility and adhesion Crospovidone nf has excellent fluidity and plastic deformation, so they have excellent adhesion. This property gives good compressibility in spraying, drying, and wet granulation. Adding PVPP tablet disintegrant to the tablet, compared with commonly used starch, cellulose preparations and pectin compounds, the hardness and abrasion resistance of the tablet are not affected, and the capping of the tablet is not reduced. Crospovidone nf can also be effectively used as a tablet disintegrant in direct compression, without the use of lubricants or the addition of binders. Capillary activity and hydration capacity Research work has shown that PVPP as a tablet disintegrant has high capillary activity and hydration capacity, because of their large specific surface area (average 1.25 m2/g) and significant water absorption (high and rapid water absorption) , Up to 60% or more). Swelling and disintegration PVPP has high capillary activity, so it can quickly absorb water into the tablet. Because the internal pressure (swelling pressure) exceeds the strength of the tablet, the tablet disintegrates instantly. And because there are folded molecular chains between the crosslinks, when water or aqueous solution penetrates, they are stretched by sudden impact and forced to separate immediately. As a result of swelling, the net volume increases (approximately doubled in 5 minutes), so that tablets prepared with PVPP tablet disintegrants disintegrate immediately.

Send Inquiry

Chat Now

Product Introduction

Property:

Compressibility and adhesion

Crospovidone nf has excellent fluidity and plastic deformation, so they have excellent adhesion. This property gives good compressibility in spraying, drying, and wet granulation. Adding PVPP tablet disintegrant to the tablet, compared with commonly used starch, cellulose preparations and pectin compounds, the hardness and abrasion resistance of the tablet are not affected, and the capping of the tablet is not reduced. Crospovidone nf can also be effectively used as a tablet disintegrant in direct compression, without the use of lubricants or the addition of binders.

Capillary activity and hydration capacity

Research work has shown that PVPP as a tablet disintegrant has high capillary activity and hydration capacity, because of their large specific surface area (average 1.25 m2/g) and significant water absorption (high and rapid water absorption) , Up to 60% or more).

Swelling and disintegration

PVPP has high capillary activity, so it can quickly absorb water into the tablet. Because the internal pressure (swelling pressure) exceeds the strength of the tablet, the tablet disintegrates instantly. And because there are folded molecular chains between the crosslinks, when water or aqueous solution penetrates, they are stretched by sudden impact and forced to separate immediately. As a result of swelling, the net volume increases (approximately doubled in 5 minutes), so that tablets prepared with PVPP tablet disintegrants disintegrate immediately.

Organic peroxidecrospovidone sds is structurally different from thermoplastics, thermosetting resins and vulcanized rubber. It has a body structure but is not completely cross-linked. The cross-linked area is small and does not have a large cross-linking network like vulcanized rubber. In terms of performance, it has the characteristics of all three, that is, it has both thermoplasticity, hardness, good solvent resistance, high elasticity and excellent low temperature resistance. Whether it is high-density polyethylene or low-density polyethylene, after crosslinking, its tensile strength, heat resistance, aging resistance and weather resistance, dimensional stability, stress crack resistance, abrasion resistance and solvent resistance are all Improved, and excellent creep resistance. The softening point of cross-linked polyethylene can reach 200℃, and the heat resistance can reach 140℃. In addition, it also has excellent electrical insulation, low temperature resistance and radiation resistance. The properties of peroxide cross-linked polyethylene.

2pvpp

Properties：

white or milky white free-flowing powder, easy to absorb moisture, odorless or slightly odorous, insoluble in water, alkali, acid and commonly used organic solvents, with strong swelling performance and complexation ability with many types of substances.

Application:

Due to the high molecular weight and cross-linked structure of cross-linked povidone, it is insoluble in water but can quickly promote the expansion of its network structure and disintegrate when exposed to water, and is widely used as a disintegrant for tablets in medicine, and is widely used as a suspension stabilizer, a complexing agent for pharmaceutical ingredients, and a complexing agent for tannins and polyphenols in plant drugs

Hot Tags: Crospovidone Vs Copovidone25249-54-1, China Crospovidone Vs Copovidone25249-54-1 manufacturers, suppliers, factory, N Vinylpyrrolidone Polymerization, , Pvp K30 Polymer, Crospovidone Category, Dispersant, pvpk30

No Information

Crospovidone Va 64 25086-89-9