Povidone, abbreviated as PVP, is a representative N-vinylamide polymer. Povidone is white to light yellow powder in appearance, slightly odorous, stable at room temperature and pressure, hydrophilic, hygroscopic in air, soluble in water, soluble in ethanol, amines, halogenated hydrocarbons, insoluble in acetone, aliphatic and other solvent hydrocarbons, and has strong complexation and adsorption capacity for various substances. Povidone is mainly used as a pharmaceutical excipient, and can be used as a binder, solubilizer, suspension agent, dispersant, thickener, stabilizer, film-forming agent, etc.
According to the relative molecular weight, povidone can be divided into homopolymers, copolymers, cross-linked polymers and other types; Povidone can be divided into soluble povidone according to the degree of polymerization, and according to the average molecular weight (expressed by K value), povidone mainly includes PVP-K17, PVP-K25, PVP-K30, PVP-K60, PVP-K90 and other products; According to the type of ion, povidone can be divided into three categories: non-ionic povidone, cationic povidone, and anionic povidone. Crospovidone, also known as insoluble povidone, abbreviated as PVPP in English, can be complexed with phenol, iodine, alkaloids, etc., to improve enzyme activity, insoluble in water, but hygroscopic, absorbent (nearly 60%) and fast, can expand after water absorption.
As a pharmaceutical excipient, crospovidone can be used as a tablet disintegrant, with excellent performance, and is a super disintegrant; It can also be used as a binder and excipient for tablets, pills, granules, etc. In addition to the pharmaceutical field, crospovidone can also be used in wine, vinegar and other brewing fields. Povidone K30 (PVP-K30) is a common povidone.
It is water-soluble povidone, soluble in water and a variety of organic solvents, and hygroscopic. As a pharmaceutical excipient, povidone K30 can be used as a binder for tablets, pills, granules, a grafting aid for capsules, a dispersant for liquid preparations, and a co-solvent for injections. As one of the new excipients, it can also be used in the fields of synthetics and pharmaceutical low-temperature preservatives. According to the "2022-2026 Povidone Industry In-depth Market Research and Investment Strategy Recommendation Report" released by Synsprit Industry Research Center, in the global market, povidone manufacturers mainly include BASF in Germany, Ashland Asia-Pacific in the United States, and Xinkaiyuan in China, and a few companies occupy the vast majority of the global povidone market. In the Chinese market, New Kaiyuan is the first enterprise to realize the large-scale production of povidone.
At this stage, povidone has a complete production scale and a complete product line. It can produce PVP-K, PVP-I, cross-linked PVP, PVP copolymer and other products. People said that due to the continuous expansion of the domestic medical market and the growing demand for drugs, povidone, as an important pharmaceutical excipient, is in rising demand. In addition to the existing application areas, new application areas of povidone are constantly expanding. It is preliminarily estimated that the demand for povidone in China will reach about 54,000 tons in 2021. From this point of view, the development of China's povidone industry is in good condition.
