Vinyl Pyrrolidone Crosslinking9003-39-8

PVPP is cross-linked polyvinylpyrrolidone, also known as cross-linked povidone. It is white or nearly white, hygroscopic and easy to flow powder, odorless or slightly odor, insoluble in water, alkali, acid and common organic solvents, and has strong swelling performance and complex ability with many types of substances.

Due to the high molecular weight and cross-linked structure of PVPP, it is insoluble in water but can quickly introduce water in contact with water, which promotes the expansion of its network structure to produce disintegration, so PVPP is a widely used tablet disintegrant in medicine.

Because the molecules have amide bonds and adsorb the hydroxyl groups on the polyphenol molecules to form hydrogen bonds, they can adsorb polyphenols and improve the non-biological stability of the wine. Therefore, it can be used as a stabilizer for beer, fruit wine, and beverage wine, extending its shelf life up to 300 days, and improving its transparency, color and taste.

1. Tableting: 2–8% w/w in direct compression

2. Hydration: Pre-swell in ethanol for hydrogel production

3. Incompatibilities: Avoid peroxides/alkaline binders (pH>9)

4. Reactivity: Exothermic gelation above 30% water content
 

Performance Validation

For Pharmaceuticals

▼ Disintegration time: 28±3 sec (USP <701>)

▼ Friability reduction: ≤0.1% in high-API formulations

▼ Dissolution variance: RSD <2% (n=12)

For Industrial Use

▼ Phenol adsorption: ≥120 mg/g

▼ Brewing turbidity: ≤0.5 NTU after treatment

▼ Hydrogel swelling: 40x dry weight in saline

 

 

This product is white or milky white powder, odorless or slightly characteristic odor, basically tasteless, insoluble in water, alkali, acid and organic solvents. It has hygroscopicity and water absorption. It swells after absorbing water, but does not form a gel; after absorbing water, the molecular chain stretches and the volume increases rapidly, and the expansion force can cause the tablet to disintegrate quickly.

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