Pvpp Sigma 25249-54-1,9003-39-8

Incompatibility: Cross-linked polyvinylpyrrolidone is compatible with most inorganic or organic acid drugs, but when exposed to water, cross-linked polyvinylpyrrolidone can react with these substances.

Safety: Cross-linked polyvinylpyrrolidone is generally considered non-toxic and non-irritating. Short-term animal studies have shown that this product has no adverse reactions. However, due to the lack of sufficient evidence, WHO has not yet established an acceptable daily intake.

LD50 (mouse, IP): 12g/kg [1]

Regulations: It is approved for use as a food additive in Europe and is included in the FDA's Inactive Ingredients Guide (oral capsules, tablets, topical, transdermal and vaginal preparations). It has been approved for use in injectable preparations in the UK.

Pharmaceutical application: due to the high molecular weight and cross-linked structure of cross-linked povidone, insoluble in water but can quickly promote its network structure to expand and disintegrate when exposed to water, it is widely used as a disintegrant for tablets in medicine, and is also widely used as a suspension stabilizer, a complexing agent for pharmaceutical ingredients, and a complexing agent for tannins and polyphenols in plant drugs. Food applications: PolyFilterTM molecules have amide bonds and adsorption of hydroxide groups on polyphenol molecules to form hydrogen bonds, so they can be used as stabilizers for beer, fruit wine/wine, and beverage wines, extending their shelf life, and improving their clarity, color, and taste. The product is available in both disposable and regenerative specifications, and the disposable product is suitable for small and medium-sized enterprises; Recycled products require the purchase of special filtration equipment, but they can be recycled and suitable for recycling in large breweries.

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