Cas 616 45 5

Emergency treatment of leakage

Protective measures, protective equipment and emergency treatment procedures for operators: Quickly evacuate personnel from the leakage contaminated area to the upwind area, and immediately isolate them, and strictly restrict entry and exit. It is recommended that emergency treatment personnel wear self-contained positive pressure respirators and anti-toxic clothing. Cut off the source of leakage as much as possible. If it is liquid, prevent it from flowing into restricted spaces such as sewers and flood drainage ditches. Small leakage: rinse with a large amount of water, and put it into the wastewater system after diluting the washing water. Large leakage: build a dike or dig a pit to contain it. Transfer it to a tank truck or a special collector with a pump, and recycle or transport it to a waste treatment site for disposal. If it is solid, collect it in a dry, clean, covered container with a clean shovel.

2.2-Substitution products at positions 1 and 3 on the pyrrolidone ring

In most cases, in addition to the substitution of the group at the nitrogen atom at position 1 on the 2-pyrrolidone ring, substitution at other positions on the ring can obtain a wider range of pharmacological activities. For example, in recent years, chemists and pharmacologists have shown increasing interest in compounds containing the α-methylene-γ-butyrolactam skeleton. This is mainly because, like α-methylene-γ-butyrolactone, α-methylene-γ-butyrolactam has physiological activities such as cytotoxicity, anti-tumor and anti-inflammatory. Studies have shown that α-methylene-γ-butyrolactone is too toxic to be used clinically. In comparison, α-methylene-γ-butyrolactam is much less toxic, so it has the potential for clinical application in cancer treatment. At present, people are constantly isolating compounds with the α-methylene-γ-butyrolactam skeleton from terrestrial and marine natural products. In addition to efforts to find compounds with this skeleton in natural products, chemists are taking different approaches to synthesize α-methylene-γ-butyrolactam derivatives with different structures for pharmacological screening.

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