N Vinyl 2 Pyrrolidone 616-45-5

2-Substitution products at positions 1 and 4 on the pyrrolidone ring and their synthesis methods

Substitution at position 4 of 2-pyrrolidone can produce many pharmacologically active compounds. Classic examples include the design of some anti-HIV drugs. Generally, the design of anti-HIV drugs can be started from three aspects: ⑴ Preventing the binding of virions to T-4 lymphocytes; ⑵ Inhibiting the reverse transcriptase of the virus; ⑶ Inhibiting HIV virus protease. Existing antiviral drugs can be divided into two categories: reverse transcriptase inhibitors and protease inhibitors. Among them, reverse transcriptase inhibitors can be divided into nucleoside reverse transcriptase inhibitors and non-nucleoside reverse transcriptase inhibitors. Since the launch of the anti-HIV drug zidovudine in the 1980s, the initial clinical use of single-drug treatment for HIV patients was basically poor, and then combined drug treatment was adopted, with significant efficacy. In view of the increasing drug resistance of HIV virus, the development of new anti-HIV drugs is imminent. A series of phenyl-substituted 2-pyrrolidone compounds were designed and synthesized, and their anti-HIV activity was investigated in order to discover a class of effective reverse transcriptase inhibitors.

Substitution products at positions 1 and 5 on 2-pyrrolidone

2-pyrrolidone derivatives that can act as potassium channel blockers were successfully synthesized. These compounds are particularly suitable as antiarrhythmic active ingredients, especially for the treatment and prevention of atrial arrhythmias, such as atrial fibrillation (AF) or atrial flutter.

Substitution products at multiple positions on the 2-pyrrolidone ring

In most cases, substitution at multiple positions on the 2-pyrrolidone ring can meet the needs of a wider range of pharmacological activities. Monoamine oxidase (MAO, EC) is a flavonoid that causes the oxidative deamination of endogenous monoamine neurotransmitters such as dopamine, 5-hydroxytryptamine, epinephrine or norepinephrine and trace amounts of amines such as phenylethylamine, as well as a large number of exogenous amines. A patent was invented to synthesize a series of pyrrolidone derivatives that can act as MAOB inhibitors.

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