N Methyl Pyrrolidone 616-45-5

2-Pyrrolidone can be used as a high-boiling point solvent for petroleum processing; to prepare N-vinylpyrrolidone, acrylonitrile, and aminobutyric acid; it can also be used as a plasticizer for coatings; under the action of benzoyl chloride and alkali metals, it can be polymerized to produce nylon-4, etc. 2-Pyrrolidone is a class of pyrrolidine compounds with a five-membered lactam ring, which is widely present in natural products and various synthetic compounds. Since pyrrolidone compounds have a variety of biological activities and are widely used in the medical field, many compounds with a variety of biological activities can be prepared by modifying and functionalizing the pyrrolidone structure.

1.2-Nitrogen atom substitution products on the pyrrolidone ring

2-Pyrrolidone has a nitrogen atom at position 1. By replacing the nitrogen atom with various groups, a wide range of pharmacological activities can be obtained. The most classic example is the invention of the nootropic drug piracetam. Piracetam, a drug developed in the early 1970s for the treatment of memory impairment and improvement of cognitive ability in patients with Alzheimer's disease, can be said to be a pyrrolidone compound used in clinical practice. Its strong central selectivity, few side effects, and non-addictive properties have aroused great interest in the development of pharmacologically active pyrrolidone compounds. Piracetam is a derivative of γ-aminobutyric acid. Later, a large number of drugs that improve brain function were developed based on the structure of piracetam by changing the substituents at positions 1 and 4 on the 2-pyrrolidone ring.

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